Post 04

The Inflammation Cluster

William Kasel·1 min read

6 genetic variants creating a pro-inflammatory profile

I eat clean. I exercise. I sleep 7-8 hours.

My inflammation marker (hs-CRP) was still 3.5 mg/L. That's cardiac risk territory.

Then I found 6 genetic variants that explained everything. 🧵

Your body has genes that DRIVE inflammation and genes that BRAKE it. I got unlucky on both sides.

Drivers (all high-activity):

Brakes (all impaired):

Three genes pushing inflammation UP. Three genes that should pull it DOWN - broken.

This is genetic. Eating broccoli wasn't going to fix it.

I needed a targeted protocol based on these specific pathways, designed with my medical team.

What actually moved the needle:

Targeted the NF-kB pathway (the master inflammation switch)
High-dose omega-3 (my FADS genes show I can't convert plant omega-3s, need preformed EPA/DHA)
Lost 50 lbs (adipose tissue is an inflammation factory)
Specific compounds targeting TNF-alpha and IL-6

Results:

hs-CRP: 3.5 → 1.0 mg/L

71% reduction.

Not from a generic "anti-inflammatory diet." From knowing WHICH inflammatory pathways were genetically overactive and targeting them specifically.

If your CRP is elevated and you're doing "everything right" - your genetics might be the missing variable.

Standard bloodwork won't show this. You need genetic testing that covers inflammatory cytokine SNPs.

The answer to "why am I inflamed?" might be in your DNA.

This is what I put in The Manual every week.