The Methylation Discovery
9 genetic variants breaking every step of methylation
Your body has a process called methylation. It runs detox, makes neurotransmitters, repairs DNA, and controls inflammation.
I have 9 genetic variants that impair it at every single step.
My doctor never tested for any of them. Here's what I found. 🧵
Methylation is a cycle. Think of it like a factory assembly line:
Step 1: Bring in raw materials (folate) Step 2: Process them (MTHFR enzyme) Step 3: Use B12 to convert homocysteine back to methionine Step 4: Create SAMe (your body's master methylation donor)
My genetic report:
- RFC1: Impaired folate TRANSPORT into cells
- MTHFR: Compound heterozygous (~50% reduced processing)
- FUT2: Can't absorb B12 from food properly
- TCN2: Can't transport B12 inside cells
- MTRR: Can't RECYCLE B12 properly
- MTR: The B12-dependent step itself is impaired
That's 6 variants hitting the same pathway from 6 different angles.
And it gets worse - even the BACKUP pathway is impaired:
- BHMT variant (the alternate route that uses betaine instead of B12)
Plus CBS and SHMT variants affecting downstream branches.
9 total. Every step.
What this means practically:
- Standard folic acid? My body can't convert it. Need methylfolate.
- Oral B12 supplements? Can't absorb them. Need injections.
- "Normal" homocysteine? Probably masking the dysfunction.
Most people with these variants have no idea. Doctors test TSH and a CBC and call it a day.
After switching to:
- Methylfolate (not folic acid)
- B12 injections (not oral pills)
- Targeted cofactors based on each specific variant
My energy, focus, and bloodwork all shifted within weeks.
Genetics isn't destiny. But it IS the instruction manual nobody gives you.
This is what I put in The Manual every week.
Subscribe to The Manual →