Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents
/MDPI/2026
Why It Matters
This caught my attention because Cordyceps is already popular as a supplement, but most people don't know what compounds actually do the work or if there's real evidence. This review maps out the specific molecules and mechanisms—though it's important to note we're still mostly looking at cell cultures and rodent studies, not human data. If you're already taking Cordyceps for brain health, this explains what might be happening, but it's not proof it works in humans yet.
Key Findings
- Cordycepin (3'-deoxyadenosine) shows anti-inflammatory effects by inhibiting NF-κB signaling and reducing pro-inflammatory cytokines in neuronal cell models
- Ergosterol and polysaccharides from Cordyceps demonstrate antioxidant activity and can cross or influence the blood-brain barrier in animal studies
- Multiple Cordyceps compounds support mitochondrial function and reduce oxidative stress markers in preclinical models of neurodegeneration
- The bioactives show promise across different neurodegenerative disease models (Alzheimer's, Parkinson's) but through overlapping rather than disease-specific mechanisms
- Bioavailability and optimal dosing in humans remain unclear—most evidence comes from isolated compounds at concentrations that may not match typical supplement doses