The anti-nociceptive effect of BPC-157 on the incisional pain model in rats
/PMC/2026
Why It Matters
This paper caught my attention because BPC-157 is all over biohacking forums, with people using it for everything from tendon injuries to gut issues. But this is pure animal data—we're talking about pain after surgical cuts in rats, not humans. The morphine-sparing effect is interesting mechanistically, but we have no idea if this translates to people or what the right dose would be. Not a doctor. Just a guy who reads the papers.
Key Findings
- Rats treated with BPC-157 showed 62% lower morphine consumption in the 24 hours following surgical incision compared to saline controls
- The peptide reduced mechanical hypersensitivity (how much pressure triggered pain withdrawal) starting at 2 hours post-surgery and lasting through 24 hours
- BPC-157 appeared to work through both central nervous system pathways and local tissue effects, not just one mechanism
- The effect was dose-dependent, with 10 μg/kg showing optimal results in this rat model
- No adverse behavioral effects were observed during the study period
Read the Paper↗PMC8995671