Stable Gastric Pentadecapeptide BPC 157 and NO-System
/Springer/2026
Why It Matters
This paper caught my attention because BPC 157 is popular in biohacking circles for injury recovery, but the mechanism has been murky. Understanding that it works through the NO system helps explain why it might affect so many different tissues — NO is involved in blood flow, inflammation, and tissue repair. That said, this is still animal research. Despite the hype online, we don't have solid human trial data on dosing, safety, or whether these effects translate to people.
Key Findings
- BPC 157 influences the nitric oxide system, which regulates blood vessel function, inflammation, and tissue repair across multiple organ systems
- Animal studies show effects on healing of blood vessels, tendons, muscles, and gastrointestinal tissues through NO-mediated pathways
- The peptide appears to modulate both the production of NO and the activity of NO synthase enzymes in damaged tissues
- Effects persist across different injury models in animals, suggesting a broad mechanism rather than tissue-specific action
- No human clinical trials with proper controls are discussed — all evidence remains preclinical