Preclinical safety evaluation of body-protective compound-157
/ScienceDirect/2026
Why It Matters
This paper caught my attention because BPC-157 is widely sold online as a "healing peptide" despite zero FDA approval or human safety data. This preclinical work suggests it's not acutely toxic in animals, but that's a far cry from knowing if it's safe for humans. The gap between "didn't kill rats" and "safe for you to inject" is enormous.
Key Findings
- No acute toxicity observed in rodents across oral, intraperitoneal, and subcutaneous administration routes at tested doses
- No evidence of organ toxicity in standard histopathological examination of major organs (liver, kidney, heart) in animal models
- Animals showed normal weight gain and behavior patterns during observation periods, suggesting no gross systemic effects
- Study used standard preclinical toxicology protocols, but lacks long-term safety data, carcinogenicity testing, or reproductive toxicity assessment
- Zero human data exists — this is pure animal research and cannot predict human safety profile, drug interactions, or long-term effects