PMID: 21295044
Ilic et al./PubMed/2011
Why It Matters
This paper caught my attention because NSAIDs like ibuprofen and diclofenac cause real problems — stomach bleeding, liver stress, even brain fog in severe cases. BPC 157 is often discussed in peptide communities, and this study shows it protected rats from these side effects. But here's the reality check: this is a rat toxicity model with deliberately massive NSAID doses. We have zero human data on whether BPC 157 would protect someone taking normal ibuprofen doses, and the mechanisms aren't fully understood.
Key Findings
- Rats given toxic diclofenac doses developed stomach ulcers, elevated liver enzymes (AST, ALT), and encephalopathy symptoms; BPC 157 treatment reduced all three types of damage
- BPC 157 worked whether given by injection or orally, and helped even when started after diclofenac exposure (not just as prevention)
- Protection was dose-dependent: 10 µg/kg worked better than lower doses in most measures
- Liver enzyme elevations (AST increased 5-fold, ALT 3-fold with diclofenac alone) were partially normalized with BPC 157 treatment
- The study used Wistar rats with deliberately toxic NSAID dosing to create severe multi-organ damage — not comparable to therapeutic human NSAID use
Read the Paper↗PMID: 21295044