Perforating corneal injury in rat and pentadecapeptide BPC 157
Masnec et al./PubMed/2015
Why It Matters
This paper caught my attention because BPC-157 gets talked about a lot in performance/recovery circles, but almost always for gut or muscle issues. Seeing it tested on eye injuries is unusual — and the results were pretty dramatic in rats. That said, this is pure animal research with surgically created injuries, not real-world corneal damage in humans. The no-new-blood-vessel finding is interesting because abnormal vessel growth in the eye can impair vision long-term.
Key Findings
- Complete corneal wound closure occurred at 72 hours with 2 μg/mL dose and 96 hours with 2 ng/mL dose, versus poor healing in water-treated controls
- Fluorescein and Seidel tests (which detect leaking wounds) turned negative starting at 24 hours in BPC-157 treated eyes
- Control rats developed new blood vessels growing from the limbus toward the wound, while BPC-157 treated rats generally had no new vessel formation
- Inflammatory cells in the aqueous humor disappeared by 96-120 hours in treated groups, indicating reduced inflammation
- The lowest dose tested (2 pg/mL) showed no significant benefit — dose appeared to matter
Read the Paper↗PMID: 25912999