Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway
/PMC/2026
Why It Matters
This paper caught my attention because BPC-157 has a cult following in biohacking circles for injury healing, but we've had almost no mechanistic data on how it actually works. Understanding that it activates nitric oxide pathways gives us a plausible explanation for some of the vascular effects people report. That said, this is preclinical only—I couldn't access details on whether this was cell culture or animal work, but either way, no human data yet.
Key Findings
- BPC-157 activates the Src-Caveolin-1-eNOS signaling pathway, which is one of the main cellular mechanisms for producing nitric oxide
- The peptide demonstrates modulatory effects on vasomotor tone—meaning it influences whether blood vessels constrict or relax
- The mechanism involves endothelial nitric oxide synthase (eNOS), the enzyme responsible for NO production in blood vessel linings
- This represents one of the first mechanistic studies showing how BPC-157 might affect vascular function at the molecular level
Read the Paper↗PMC7555539