Review/Commentary

Metformin: the next angiogenesis panacea?

/PMC/2021

Why It Matters

Describes metformin as promoting VEGF-mediated angiogenesis, despite being one of the most widely prescribed medications globally. Demonstrates that pro-angiogenic ≠ pro-cancer.

Key Findings

  • Metformin promotes VEGF-mediated angiogenesis at therapeutic doses
  • Despite being pro-angiogenic, metformin is associated with reduced cancer risk