BPC-157 PD Study - PubMed
Sikiric et al./PubMed/2000
Why It Matters
This paper caught my attention because it's one of the earliest studies showing BPC-157 might affect the brain, not just tissue repair. The effects are dramatic — preventing death and reversing paralysis in two different Parkinson's models. But this is mouse data from 2000, and I can't find follow-up human trials despite the strong results. That's a red flag. Without human data after 24 years, this stays firmly in the 'interesting but unproven' category.
Key Findings
- BPC-157 given at 1.5 micrograms or 15 nanograms per kg (both doses worked) prevented tremor, paralysis, and death in mice given MPTP, a toxin that causes Parkinson's-like symptoms
- The peptide worked both before toxin exposure (prevention) and after (treatment) — reversing complete paralysis that had already developed 24 hours earlier in reserpine-treated mice
- BPC-157 reduced MPTP-induced hyperactivity and improved spatial orientation that the toxin had impaired
- The peptide also protected stomach tissue from lesions caused by MPTP, consistent with its known gastric protective effects
- Effects seen at both microgram and nanogram doses, suggesting activity across a 100-fold dose range
Read the Paper↗PMID: 10672997