Post 07

My Morning Protocol

William Kasel·2 min read

What you actually do every morning, mapped to genetics

01

My morning protocol takes about 5 minutes.

Every single thing in it maps to a specific genetic variant or biomarker result.

Here's the full stack and the reasoning behind each item. 🧵

02

Step 1: NAD+ (200mg, intramuscular injection)

NAD+ declines ~50% between age 40-60. It's critical for DNA repair, mitochondrial function, and cellular energy.

I inject rather than supplement orally because oral bioavailability of NAD+ is essentially zero.

03

Step 2: BPC-157 (500mcg, subcutaneous)

I have chronic GI issues. BPC-157 is a peptide with strong preclinical evidence for gut healing — over 100 animal studies, no observed toxicity at any dose tested. The human trial data is limited and I'm honest about that.

My source is a 503A & 503B compounding pharmacy with DEA Schedule 2 certification. That's the highest level of regulatory scrutiny a pharmacy can have. Sourcing matters more than most people realize.

04

Step 3: Methylated B12 injection (subcutaneous)

9 methylation variants (see my earlier thread). I cannot absorb B12 from food (FUT2), can't transport it into cells well (TCN2), can't recycle it (MTRR).

Oral B12 is useless for my genetics. Injections bypass every broken step.

05

Step 4: Semax (intranasal, weekdays only)

COMT Val/Val + DBH high-activity = dopamine-poor profile. Semax is a nootropic peptide that modulates BDNF and has mild dopaminergic effects.

Weekdays only. Weekends off. Cycling to avoid tolerance.

06

Plus the supplement stack:

  • Methylfolate (MTHFR)
  • High-dose fish oil (FADS1/2 variants - can't convert plant omega-3s)
  • D3 + K2 (VDR variant - need higher dose)
  • Magnesium glycinate (COMT cofactor + sleep)
  • Selenium (inflammation cluster)

Every item traces back to a genetic variant or a lab result. Nothing is here by default. And I'll be upfront: the evidence levels vary. Methylfolate and B12 have decades of human data. The peptides have strong preclinical data but limited human trials. I know the difference and I think you should too.


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