Genetic Profile

178 SNPs analyzed from 23andMe v4 chip data (January 2026). Interpreted against ClinVar, PharmGKB, and published literature.40 key actionable variants shown below across 9 systems.

Genetics are probabilistic, not deterministic. Having a variant doesn't mean you'll develop a condition — it shifts the probability. This is one person's data interpreted against published research. Consult a genetic counselor before making medical decisions based on SNP data.

Note: Genetic data partially reveals information about biological relatives. Family members were consulted before publication.

178

SNPs analyzed

9

systems mapped

APOE e2/e2

Alzheimer's protection

O

Blood type

GeneGenotypeRiskEffect
MTHFR C677T (rs1801133)AG (Het)high~35% reduced enzyme function
MTHFR A1298C (rs1801131)GT (Het)highAdditional reduction, combined = ~50-60%
MTRR (rs1801394)AA (Homo)highReduced B12 recycling
FUT2 (rs601338)AA (Homo)highNon-secretor, poor gut B12 absorption
MTR (rs1805087)AGmoderateImpaired B12-dependent remethylation
TCN2 (rs1801198)CGmoderateImpaired B12 cellular transport
RFC1 (rs1051266)CC (variant)highImpaired folate transport into cells
BHMT (rs3733890)CTmoderateBackup pathway also impaired
CBS (rs234706)CTmoderateDownstream transsulfuration affected

Protocol: Methylated B-complex (Neuro 110), B12 injections daily, methylfolate

Result: Homocysteine: 10.8 umol/L (borderline). B12: 442 pg/mL (adequate with injections). Folate: 9.3 ng/mL (optimal).

GeneGenotypeRiskEffect
IL-6 (rs1800795)GGhighHigher baseline IL-6 production
TNF-alpha (rs1800629)GGhighHigher TNF-alpha drive
IL-1beta (rs16944)GGhighHigher IL-1beta production
IL-10 (rs1800896)TThighReduced anti-inflammatory brake
CRP (rs1205)CChighGenetically elevated CRP baseline
IL2RA (rs2104286)TThighImpaired T-regulatory cells

Protocol: Curcumin phytosome 1g, Omega-3 (LPC form), NAC 600mg, GHK-Cu, KPV, weight loss (50 lbs)

Result: hs-CRP: 3.5 → 1.0 mg/L (-71%). Confirms genetic tendency AND intervention effectiveness.

GeneGenotypeRiskEffect
COMT (rs4680)AA (Val/Val)highFast dopamine clearance — "Warrior" type
DBH (rs1611115)CChighHigh dopamine→norepinephrine conversion
MAO-A (rs6323)T (hemizygous)moderateHigh activity — fast serotonin + dopamine breakdown
SLC6A4 (rs25531)DelmoderateReduced serotonin transporter expression
COMT (rs4633)TTmoderateLower pain tolerance

Protocol: Semax (neuropeptide), Magnesium L-Threonate (COMT cofactor), Methylene Blue 5mg

GeneGenotypeRiskEffect
FADS1 (rs174547)Hethigh~50% reduced ALA→EPA conversion
FADS2 (rs174575)HethighImpaired delta-6 desaturase

Protocol: Accentrate Omega Max (LPC form: 390mg LPC, 210mg EPA, 105mg DHA)

GeneGenotypeRiskEffect
DIO2 (rs225014)TT (Homo)moderateSignificantly reduced T4→T3 conversion

Protocol: Selenium (via stack), monitoring

Result: TSH: 1.08 (optimal). Free T3: 3.3 (optimal). Currently compensating despite genetics.

GeneGenotypeRiskEffect
BCMO1 (rs12934922)AT (Het)moderate~51% reduced beta-carotene → vitamin A
PEMT (rs12325817)TT (Homo)highIncreased choline requirement
CYP4F2 (rs2108622)CTmoderateFaster vitamin K metabolism
SOD2 (rs4880)GGmoderateMitochondrial oxidative stress
GCLM (rs41303970)AGmoderate~20-30% reduced glutathione synthesis
SUOX (rs705702)AGlowMildly reduced sulfite oxidase
TMPRSS6 (rs855791)AG/AAlowLower iron absorption tendency

Protocol: Ubiquinol 100mg, NAC 600mg, Glutathione 500mg, K2 MK-7 100mcg

GeneGenotypeRiskEffect
FKBP5 (rs3800373)AAmoderateMore reactive HPA axis
MTNR1B (rs10830963)GGlowReduced melatonin signaling

Protocol: Ashwagandha 600mg, Melatonin

GeneGenotypeRiskEffect
8q24 (rs6983267)GG (Homo)highColorectal cancer risk — homozygous
ERCC2 (rs13181)TTmoderateReduced UV DNA repair

Protocol:

GeneGenotypeRiskEffect
CYP1A2 (Caffeine) (rs762551)AClowIntermediate metabolizer
ADH1B (Alcohol) (rs1229984)CClowSlower metabolism
SLCO1B1 (Statins) (rs4149056)TTlowNormal tolerance
CYP2C19 (Plavix) (rs4244285)GGlowNormal metabolism
OPRM1 (Opioids) (rs1799971)AGlowMay need slightly higher doses
MAO-B (rs1799836)T (hemizygous)moderateLOW activity — berberine concern

Protocol:

Protective Genetics

APOEe2/e2 (TT/CC)
Strong Alzheimer's & CVD protection(~1% of population)
ACTN3CC
Power athlete, fast-twitch muscle fibers
FUT2AA
Norovirus resistance (non-secretor)(~20% of population)
Factor V LeidenNormal
No clotting disorder
LEP/LEPR (Leptin)GG/AA
Normal leptin signaling — GLP-1 medications optimal

Ancestry

71%

European

15.6%

Native American

1.5%

Sub-Saharan African

11.9%

Other

Paternal haplogroup: I-M26 (Sardinian/Western European)
Maternal haplogroup: H1c1 (European)
Neanderthal variants: 247 (17.3th percentile)
Blood type: O (universal donor)